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دکتر اصلان احمدی / مقالات تخصصی / More organ preservation with less morbidity in patients with pyriform sinus apex SCC
مدت زمان مطالعه ۱ دقیقه

More organ preservation with less morbidity in patients with pyriform sinus apex SCC

Introduction

Hypopharynx consists of 4 subdivisions: posterior and lateral
pharyngeal walls, pyriform sinuses, and post cricoid region [1]. Hypopharyngeal
squamous cell carcinoma (SCC) makes up nearly 95% of
hypopharyngeal cancers with the pyriform sinuses being the most frequent
site [2]. Although rare (3–5% of all head and neck SCC), they are
highly aggressive and yield the worst prognosis among all head and
neck malignancies, with a 5-year survival of 30–35% [3–5]. These
neoplasms usually spread submucosally in early stages with little to no
clinical or radiologic manifestation [6], therefore, they are usually diagnosed
at late stages when the tumor becomes large enough to obstruct
food passage and cause dysphagia [7,8]. According to previous
studies, 60–80% and 40% of patients with hypopharyngeal SCC have
ipsilateral nodal involvement and contralateral metastasis on their first
presentation

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