Background: Different inflammatory mechanisms take part in the immunopathogenesis of chronic rhinosinusitis (CRS).
Immunoglobulin (Ig) A is the first-line defense in the airway tracts and other mucosal sites, but little is reported regarding its serum
level in CRS patients. The purpose of current study is to determine the serum levels of total IgA, and its subclasses (IgA1, and IgA2) in
CRS with nasal polyps (CRSwNP), CRS without nasal polyps (CRSsNP), and control groups.
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