Background: Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease affecting paranasal sinuses. CRS is
categorized into two distinct subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps
(CRSsNP). Although several immune cells are involved in the CRS pathogenesis, the role of T cells is not fully understood.
The objective of the present study was to evaluate the frequency of CD4+
T cells and macrophages
in the sinonasal mucosa of CRS patients, as well as to investigate the specific transcription factors for Th1, Th2, Th17,
and Treg cells.